COGA Blog

Here is a place to read about research findings from COGA. You can learn about the development and progression of AUD, risk and protective factors, genetic findings, treatment for and recovery from AUD, disorders that sometimes occur along with AUD, and more. A complete list of the scientific papers that have been published using COGA data can be found here.

Genetic Nurture Effects for Alcohol Use Disorder

Genetic factors play an important role in the intergenerational transmission of alcohol use disorder. Typically, when we think about how genetic risk is passed from generation to generation, we think about the genotypes that children inherit from their parents. Yet, this represents only one potential way that genetic risk may be transmitted in families. This [...]

Parsing Genetically Influenced Risk Pathways: Genetic Loci Impact Problematic Alcohol Use Via Externalizing and Specific Risk

In this analysis, we parsed the genetic variance of problematic alcohol use (ALCP) into that which is shared with other externalizing traits and that which is not. The genetic correlations for the ALCP-specific variance differ for correlations with ALCP that includes variance which overlaps with externalizing. The ALCP-specific variance is primarily associated with alcohol [...]

Alcohol Reverses the Effects of KCNJ6 (GIRK2) Noncoding Variants on Excitability of Human Glutamatergic Neurons

People diagnosed with alcohol use disorder have been studied to identify genes linked with their diagnosis as well as other measurements such as EEG/behavioral tests.  Previous work has linked these EEG measurements with variations in and near KCNJ6, a gene encoding a potassium channel protein.  To study this, we prepared induced pluripotent stem cells using [...]

How Do Our Genes Influence Risk for Alcohol Problems?

Some people are more at risk for developing alcohol problems than others and part of the reason lies in our genes. Researchers are working on finding the specific genes associated with alcohol problems, and then mapping the complex pathways by which these genes influence alcohol use outcomes and interact with the environment. Check out Translational [...]

Alcohol Use Disorder, Psychiatric Comorbidities, Marriage and Divorce in a High-risk Sample

Previous studies demonstrate the associations between alcohol use disorders (AUD) and marital outcomes in general population samples, and the associations between AUD and marital outcomes have tangible costs, because a body of work shows links between marriage with better health and well-being. This study made use of data from the Collaborative Study on the [...]

Binge and High-Intensity Drinking – Laboratory Assessment and Underlying Risk Factors

Some patterns of alcohol consumption are riskier than others. How rapid consumption of alcohol contributes to the increased risk of alcohol use disorder is unclear. We developed an experiment in which participants were given specific control over how quickly their breath alcohol concentration (BrAC) changes, and then tested for relationships to risky drinking patterns. [...]

The Research is In: It’s Nature AND Nurture

Science tells us that both our genes AND our environments shape the likelihood that we will develop problems with alcohol use. Because the COGA study has a wealth of data on both genetics and environments, our investigators are uniquely positioned to explore both simultaneously. See the summaries of a few recent publications to better understand [...]

The Importance of Genes When Determining Risk

Alcohol use disorder is genetically influenced, but there’s no one gene that influences risk. We can now measure one’s genetic vulnerability to some common disorders using polygenic risk scores (PRS), which combine the effects of many genes into a single risk score. At the moment, PRS summarize only a small portion of an individual’s [...]

Exploring Externalizing Behavior in COGA

“Externalizing” refers to a spectrum of behaviors and disorders related to impulse control. It includes substance use disorders, behavioral outcomes like risky sex, and childhood outcomes like ADHD or behavior problems. One of the ways genes influence risk for alcohol use disorders is through externalizing pathways. COGA investigators have been at the front line of [...]

News You Can Use: How does Service Use for Alcohol Problems Relate to your Generation?

What was studied and why? Understanding the context around why people seek out help and treatment (aka services) for alcohol problems can help researchers and clinicians to better study and support those same individuals’ treatment and recovery. Service use patterns for alcohol problems have changed over the years, whether it be due to policy (e.g., [...]

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