COGA Blog

Here is a place to read about research findings from COGA. You can learn about the development and progression of AUD, risk and protective factors, genetic findings, treatment for and recovery from AUD, disorders that sometimes occur along with AUD, and more. A complete list of the scientific papers that have been published using COGA data can be found here.

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Predictors of Risk and Resilience for Future Alcohol Problems Associated with a Low Level of Response to Alcohol

Researchers investigated future prevention protocols for reducing heavy drinking and alcohol-related issues in individuals with a low response to alcohol, a genetically influenced risk factor for recurring alcohol problems. Recent research has shown that addressing factors such as associating with heavy drinking peers, holding inaccurate beliefs about the benefits of heavy drinking, and using alcohol [...]

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A Critical Review Of Ethanol Effects On Neuronal Firing: A Metabolic Perspective

The metabolism of ethanol within neurons has been an area of relative understudy, notwithstanding the recognized influence of alterations in neuronal metabolism on their functional activity. Recent investigations indicate a preferential utilization of ethanol over glucose as a carbon and energy source by neurons, inducing a reprogramming effect that leads to a diminished energy potential [...]

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Principal Component Analysis Corrects Collider Bias in Polygenic Risk Score Effect Size Estimation

In this article, researchers explore an approach to correct collider bias persisting in existing cohort studies, specifically in genetic risk scoring for studying predispositions in certain study models. Genetic risk scoring is a widely used method to study predispositions to complex traits, including behaviors and psychiatric outcomes. However, statistical models, crafted to eliminate alternative explanations [...]

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Genomic Analysis Of 1.5 Million People Uncovers Genes Related To Addiction, Antisocial Behavior, And Disease

Externalizing behaviors encompass a range of traits tied to self-regulation, like substance use disorders and childhood behavior problems, significantly influencing an individual’s life path. Previous research hinted at a shared genetic inclination for these behaviors, yet a comprehensive study to identify the responsible genes on a large scale was absent.     This study delves [...]

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The Collaborative Study On The Genetics Of Alcoholism: Functional Genomics.

The Collaborative Study on the Genetics of Alcoholism (COGA) has been exploring these elements and has identified potential genes associated with the risk of Alcohol Use Disorder (AUD) through comprehensive genetic studies. In this fifth section, COGA continues with its investigation, by further diving into how genetics affect the body’s function in the context of AUD. COGA [...]

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The Collaborative Study on the Genetics of Alcoholism: Brain Function

Alcohol use disorder and its related health problems come from a mix of genes, brain activity, and environment, affecting people differently as they grow. In this section, COGA has looked at how the brain works in relation to alcohol use risks and problems. They use brain tests and family info to separate the risks linked [...]

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The Collaborative Study On The Genetics Of Alcoholism: Genetics

This review presents a comprehensive evaluation of genetic methodologies and findings stemming from the family-centered Collaborative Study on the Genetics of Alcoholism (COGA). COGA’s primary objective was to identify genes influencing the susceptibility to alcohol use disorder (AUD) and its related complications. Notably, COGA was an early adopter of genome-wide association studies (GWAS) while also [...]

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The Collaborative Study On The Genetics Of Alcoholism: Sample and Clinical Data

This article offers an overview of the methodologies offered in collecting data for the COGA study and also dives into the characteristics of the study sample and clinical information. This is a second installment of a 5 paper series.  The Collaborative Study on the Genetics of Alcoholism (COGA) is a comprehensive multidisciplinary research initiative aimed at [...]

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The Collaborative Study on the Genetics of Alcoholism: Overview

Alcohol use disorders (AUD) are common conditions influenced by both genetics and the environment. They can lead to various problems related to excessive alcohol consumption. To comprehensively investigate the causes and consequences of alcohol-related milestones, including AUD and associated psychiatric conditions, the Collaborative Study on the Genetics of Alcoholism (COGA) was established in 1989.  COGA [...]

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Multivariate Genome-wide Association Meta-analysis Of Over 1 Million Subjects Identifies Loci Underlying Multiple Substance Use Disorders

This comprehensive study investigates the genetic factors contributing to substance use disorders (SUDs), including alcohol, tobacco, cannabis, and opioid use. It encompasses a vast dataset with over a million participants, representing diverse populations.    Researchers took several steps to investigate the genetic factors associated with substance use disorders (SUDs). First, they categorized the effects of [...]

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