Fact – COGA

Alcohol Milestones And Internalizing, Externalizing, And Executive Function: Longitudinal And Polygenic Score Associations

Posted on May 29, 2024 by Priscille Myrthil-Harder

Researchers investigated the relationships between alcohol use, behavioral traits (such as impulsivity and negative emotions), and genetic risk. Using data from 3,681 participants aged 11 to 36, researchers examined how behavioral traits and genetic risk factors are linked to different stages of alcohol use (first drink, intoxication, AUD symptoms, AUD diagnosis). The study found that […]

Associations Between Alcohol Use Disorder Polygenic Score And remission In Participants From High-risk Families And The Indiana Biobank

Posted on March 12, 2024 (March 10, 2024) by Priscille Myrthil-Harder

A prior study indicated a positive correlation between a polygenic score for AUD (PGSAUD) and the severity of AUD symptoms, as measured by the DSM-5 lifetime criterion count. Moreover, the severity of AUD symptoms was inversely related to the likelihood of achieving remission. Building on these findings, the researchers hypothesized that the PGSAUD might also […]

Neurogenetic And Multi-omic Sources Of Overlap Among Sensation Seeking, Alcohol Consumption, And Alcohol Use Disorder

Posted on March 10, 2024 (March 10, 2024) by Priscille Myrthil-Harder

This study found that the desire for new and exciting experiences (sensation seeking) is linked to how much alcohol people consume, both in adults and teenagers. The connection between sensation seeking and alcohol use disorder (AUD) seems to be mainly due to increased alcohol consumption rather than directly causing more problems. The researchers used advanced […]

Genomic Analysis Of 1.5 Million People Uncovers Genes Related To Addiction, Antisocial Behavior, And Disease

Posted on January 10, 2024 by Priscille Myrthil-Harder

Externalizing behaviors encompass a range of traits tied to self-regulation, like substance use disorders and childhood behavior problems, significantly influencing an individual’s life path. Previous research hinted at a shared genetic inclination for these behaviors, yet a comprehensive study to identify the responsible genes on a large scale was absent. This study delves […]

The Collaborative Study On The Genetics Of Alcoholism: Functional Genomics.

Posted on December 7, 2023 (January 9, 2024) by Priscille Myrthil-Harder

The Collaborative Study on the Genetics of Alcoholism (COGA) has been exploring these elements and has identified potential genes associated with the risk of Alcohol Use Disorder (AUD) through comprehensive genetic studies. In this fifth section, COGA continues with its investigation, by further diving into how genetics affect the body’s function in the context of AUD. COGA […]

The Collaborative Study on the Genetics of Alcoholism: Brain Function

Posted on November 30, 2023 by Priscille Myrthil-Harder

Alcohol use disorder and its related health problems come from a mix of genes, brain activity, and environment, affecting people differently as they grow. In this section, COGA has looked at how the brain works in relation to alcohol use risks and problems. They use brain tests and family info to separate the risks linked […]

The Collaborative Study On The Genetics Of Alcoholism: Sample and Clinical Data

Posted on November 8, 2023 (November 8, 2023) by Priscille Myrthil-Harder

This article offers an overview of the methodologies offered in collecting data for the COGA study and also dives into the characteristics of the study sample and clinical information. This is a second installment of a 5 paper series. The Collaborative Study on the Genetics of Alcoholism (COGA) is a comprehensive multidisciplinary research initiative aimed at […]

The Collaborative Study on the Genetics of Alcoholism: Overview

Posted on November 1, 2023 (November 8, 2023) by Priscille Myrthil-Harder

Alcohol use disorders (AUD) are common conditions influenced by both genetics and the environment. They can lead to various problems related to excessive alcohol consumption. To comprehensively investigate the causes and consequences of alcohol-related milestones, including AUD and associated psychiatric conditions, the Collaborative Study on the Genetics of Alcoholism (COGA) was established in 1989. COGA […]