COGA Data Publications

List of Articles Published by Other Research Teams Using the Data Shared by the Collaborative Study on the Genetics of Alcoholism (COGA)


Total number of published articles: 153


2024 [1 Article]

  1. Gershon E, Xia C, Alliey-Rodriguez N, Tamminga C, Keshavan M, Pearlson G, Keedy S, Parker D, Lencer R, Hill S (2024) Trans-Ancestry Analysis of Psychosis Biotypes: Shared Polygenic Risk and Unique Genomic Associations. Research Square; DOI: 10.21203/

2023 [2 Articles]

  1. Benca-Bachman CE, Bubier J, Syed RA, Romero Villela PN, Palmer RHC (2023) Polygenic influences on the behavioral effects of alcohol withdrawal in a mixed-ancestry population from the collaborative study on the genetics of alcoholism (COGA). Molecular and Cellular Neuroscience, 125, 103851. PMID: 37031923. DOI: 10.1016/j.mcn.2023.103851.

  2. Odintsova VV, Hagenbeek FA, van der Laan CM, van de Weijer S, Boomsma DI (2023) Genetics and epigenetics of human aggression. Handbook of Clinical Neurology, 197, 13-44. PMID: 37633706; DOI: 10.1016/B978-0-12-821375-9.00005-0.

2022 [3 Articles]

  1. Liu H, Li G, Sturgis EM, Shete S, Dahlstrom KR, Du M, Amos CI, Christiani DC, Lazarus P, Wei Q (2022) Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck. International Journal of Cancer, 151(4), 553-564. PMID: 35404482; PMCID: PMC9203942; DOI: 10.1002/ijc.34023.

  2. Mathews C, de Leeuw C, Goudriaan A, Smit A, Yu D, Scharf J, Verheijen M, Posthuma D (2022) Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis. eScholarship. LINK.

  3. Orihara S, Goto A, Taguri M (2022) Instrumental variable estimation of causal effects with applying some model selection procedures under binary outcomes. Behaviormetrika, 50(1), 241-262. DOI: 10.1007/s41237-022-00177-9.

2021 [1 Article]

  1. Luo X, Guo X, Luo X, Tan Y, Zhang P, Yang K, Xie T, Shi J, Zhang Y, Xu J, Zuo L, Li CR (2021) Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence. Addiction Biology, 26(2), e12888. PMID: 32115811; PMCID: PMC7641293; DOI: 10.1111/adb.12888.

2020 [2 Articles]

  1. Donvito G, Muldoon PP, Jackson KJ, Ahmad U, Zaveri NT, McIntosh JM, Chen X, Lichtman AH, Damaj MI (2020) Neuronal nicotinic acetylcholine receptors mediate ∆(9) -THC dependence: Mouse and human studies. Addiction Biology, 25(1), e12691. PMID: 30378732; PMCID: PMC6509006; DOI: 10.1111/adb.12691.

  2. Shete S, Liu H, Wang J, Yu R, Sturgis EM, Li G, Dahlstrom KR, Liu Z, Amos CI, Wei Q (2020) A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck. Cancer Research, 80(12), 2451-2460. PMID: 32276964; PMCID: PMC7299763; DOI: 10.1158/0008-5472.CAN-19-2360.

2019 [4 Articles]

  1. Sadeh N, Spielberg JM, Logue MW, Hayes JP, Wolf EJ, McGlinchey RE, Milberg WP, Schichman SA, Stone A, Miller MW (2019) Linking genes, circuits, and behavior: network connectivity as a novel endophenotype of externalizing. Psychological Medicine, 49(11), 1905-1913. PMID: 30207258; PMCID: PMC6414280; DOI: 10.1017/S0033291718002672.

  2. Wang K, Chen X, Ward SC, Liu Y, Ouedraogo Y, Xu C, Cederbaum AI, Lu Y (2019) CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. International Journal of Obesity (2005), 43(3), 475-486. PMID: 29568101; PMCID: PMC6102101; DOI: 10.1038/s41366-018-0037-x.

  3. Xiang B, Yang BZ, Zhou H, Kranzler H, Gelernter J (2019) GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 180(1), 3-11. PMID: 30488612; PMCID: PMC6918694; DOI: 10.1002/ajmg.b.32692.

  4. Zarrei M, Burton CL, Engchuan W, Young EJ, Higginbotham EJ, MacDonald JR, Trost B, Chan AJS, Walker S, Lamoureux S, Heung T, Mojarad BA, Kellam B, Paton T, Faheem M, Miron K, Lu C, Wang T, Samler K, Wang X, Costain G, Hoang N, Pellecchia G, Wei J, Patel RV, Thiruvahindrapuram B, Roifman M, Merico D, Goodale T, Drmic I, Speevak M, Howe JL, Yuen RKC, Buchanan JA, Vorstman JAS, Marshall CR, Wintle RF, Rosenberg DR, Hanna GL, Woodbury-Smith M, Cytrynbaum C, Zwaigenbaum L, Elsabbagh M, Flanagan J, Fernandez BA, Carter MT, Szatmari P, Roberts W, Lerch J, Liu X, Nicolson R, Georgiades S, Weksberg R, Arnold PD, Bassett AS, Crosbie J, Schachar R, Stavropoulos DJ, Anagnostou E, Scherer SW (2019) A large data resource of genomic copy number variation across neurodevelopmental disorders. NPJ Genomic Medicine, 4, 26. PMID: 31602316; PMCID: PMC6779875; DOI: 10.1038/s41525-019-0098-3.

2018 [6 Articles]

  1. Cabana-Dominguez J, Arenas C, Cormand B, Fernandez-Castillo N (2018) MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence. Translational Psychiatry, 8(1), 173. PMID: 30166527; PMCID: PMC6117282; DOI: 10.1038/s41398-018-0224-5.

  2. Liu D, Zhang H (2018) Residuals and Diagnostics for Ordinal Regression Models: A Surrogate Approach. Journal of the American Statistical Association, 113(522), 845-854. PMID: 30220754; PMCID: PMC6133273; DOI: 10.1080/01621459.2017.1292915.

  3. Pineda-Cirera L, Cabana-Dominguez J, Roncero C, Cozar M, Grau-Lopez L, Abad AC, Martinez-Luna N, Robles-Martinez M, Sanchez-Mora C, Ramos-Quiroga JA, Casas M, Ribases M, Fernandez-Castillo N, Cormand B (2018) Evaluation of previous substance dependence genome-wide significant findings in a Spanish sample. Drug and Alcohol Dependence, 187, 358-362. PMID: 29715653; DOI: 10.1016/j.drugalcdep.2018.03.013.

  4. Rabinowitz JA, Musci RJ, Milam AJ, Benke K, Uhl GR, Sisto DY, Ialongo NS, Maher BS (2018) The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders. Drug and Alcohol Dependence, 191, 365-373. PMID: 30195949; PMCID: PMC8005265; DOI: 10.1016/j.drugalcdep.2018.07.016.

  5. Sulovari A, Liu Z, Zhu Z, Li D (2018) Genome-wide meta-analysis of copy number variations with alcohol dependence. Pharmacogenomics Journal, 18(3), 398-405. PMID: 28696413; DOI: 10.1038/tpj.2017.35.

  6. Zhang H, Liu D, Zhao J, Bi X (2018) Modeling Hybrid Traits for Comorbidity and Genetic Studies of Alcohol and Nicotine Co-Dependence. Annals of Applied Statistics, 12(4), 2359-2378. PMID: 30666272; PMCID: PMC6338437; DOI: 10.1214/18-AOAS1156.

2017 [9 Articles]

  1. Jensen KP, Smith AH, Herman AI, Farrer LA, Kranzler HR, Sofuoglu M, Gelernter J (2017) A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Molecular Psychiatry, 22(2), 242-249. PMID: 27067016; PMCID: PMC5390815; DOI: 10.1038/mp.2016.43.

  2. Liu D, Zhang H (2018) Residuals and Diagnostics for Ordinal Regression Models: A Surrogate Approach. Journal of the American Statistical Association, 113(522), 845-854. PMID: 30220754; PMCID: PMC6133273; DOI: 10.1080/01621459.2017.1292915.

  3. Martinez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM (2017) Enhancing VTA Ca(v)1.3 L-type Ca(2+) channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Molecular Psychiatry, 22(12), 1735-1745. PMID: 28194001; PMCID: PMC5555837; DOI: 10.1038/mp.2017.9.

  4. Melroy-Greif WE, Simonson MA, Corley RP, Lutz SM, Hokanson JE, Ehringer MA (2017) Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. Nicotine Tob Res, 19(4), 417-425. PMID: 27613895; PMCID: PMC5868095; DOI: 10.1093/ntr/ntw200.

  5. Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J (2017) Genome-wide association study of body mass index in subjects with alcohol dependence. Addiction Biology, 22(2), 535-549. PMID: 26458734; PMCID: PMC5102811; DOI: 10.1111/adb.12317.

  6. Wang J, Talluri R, Shete S (2017) Selection of X-chromosome Inactivation Model. Cancer Informatics, 16, 1176935117747272. PMID: 29308008; PMCID: PMC5751921; DOI: 10.1177/1176935117747272.

  7. Wang M, Huang J, Liu Y, Ma L, Potash JB, Han S (2017) COMBAT: A Combined Association Test for Genes Using Summary Statistics. Genetics, 207(3), 883-891. PMID: 28878002; PMCID: PMC5676236; DOI: 10.1534/genetics.117.300257.

  8. Yang HC, Chen IC, Tsay YC, Li ZR, Chen CH, Hwu HG, Chen CH (2017) Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism. Scientific Reports, 7(1), 1975. PMID: 28512340; PMCID: PMC5434012; DOI: 10.1038/s41598-017-01791-4.

  9. Zollanvari A, Alterovitz G (2017) SNP by SNP by environment interaction network of alcoholism. BMC Systems Biology, 11(Suppl 3), 19. PMID: 28361705; PMCID: PMC5374593; DOI: 10.1186/s12918-017-0403-7.

2016 [10 Articles]

  1. Bidwell LC, Palmer RH, Brick L, McGeary JE, Knopik VS (2016) Genome-wide single nucleotide polymorphism heritability of nicotine dependence as a multidimensional phenotype. Psychological Medicine, 46(10), 2059-2069. PMID: 27052577; PMCID: PMC4925274; DOI: 10.1017/s0033291716000453.

  2. Clarke TK, Smith AH, Gelernter J, Kranzler HR, Farrer LA, Hall LS, Fernandez-Pujals AM, MacIntyre DJ, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, Thomson PA, Porteous DJ, Deary IJ, McIntosh AM (2016) Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addiction Biology, 21(2), 469-480. PMID: 25865819; PMCID: PMC4600406; DOI: 10.1111/adb.12245.

  3. Li M, Wei C, Wen Y, Wang T, Lu Q (2016) Detecting Gene-Gene Interactions Associated with Multiple Complex Traits with U-Statistics. Current Genomics, 17(5), 403-415. PMID: 28479869; PMCID: PMC5320542; DOI: 10.2174/1389202917666160513100946.

  4. Melroy-Greif WE, Vadasz C, Kamens HM, McQueen MB, Corley RP, Stallings MC, Hopfer CJ, Krauter KS, Brown SA, Hewitt JK, Ehringer MA (2016) Test for association of common variants in GRM7 with alcohol consumption. Alcohol, 55, 43-50. PMID: 27788777; PMCID: PMC5123698; DOI: 10.1016/j.alcohol.2015.10.005.

  5. Palmer RH, Nugent NR, Brick LA, Bidwell CL, McGeary JE, Keller MC, Knopik VS (2016) Evidence of Shared Genome-Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users. Journal of Traumatic Stress, 29(3), 197-204. PMID: 27214850; PMCID: PMC6344111; DOI: 10.1002/jts.22103.

  6. Perry BL (2016) Gendering Genetics: Biological Contingencies in the Protective Effects of Social Integration for Men and Women. American Journal of Sociology, 121(6), 1655-1696. PMID: 27416652; DOI: 10.1086/685486.

  7. Sadeh N, Wolf EJ, Logue MW, Lusk J, Hayes JP, McGlinchey RE, Milberg WP, Stone A, Schichman SA, Miller MW (2016) Polygenic Risk for Externalizing Psychopathology and Executive Dysfunction in Trauma-Exposed Veterans. Clinical Psychological Science, 4(3), 545-558. PMID: 27453802; PMCID: PMC4951156; DOI: 10.1177/2167702615613310.

  8. Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J (2016) Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry, 73(5), 472-480. PMID: 27028160; PMCID: PMC4974817; DOI: 10.1001/jamapsychiatry.2016.0036.

  9. Uddin M, Pellecchia G, Thiruvahindrapuram B, D’Abate L, Merico D, Chan A, Zarrei M, Tammimies K, Walker S, Gazzellone MJ, Nalpathamkalam T, Yuen RK, Devriendt K, Mathonnet G, Lemyre E, Nizard S, Shago M, Joseph-George AM, Noor A, Carter MT, Yoon G, Kannu P, Tihy F, Thorland EC, Marshall CR, Buchanan JA, Speevak M, Stavropoulos DJ, Scherer SW (2016) Indexing Effects of Copy Number Variation on Genes Involved in Developmental Delay. Scientific Reports, 6, 28663. PMID: 27363808; PMCID: PMC4929460; DOI: 10.1038/srep28663.

  10. Zhao J, Zhang H (2016) Modeling Multiple Responses via Bootstrapping Margins with an Application to Genetic Association Testing. Statistics and Its Interface, 9(1), 47-56. PMID: 26543519; PMCID: PMC4629876; DOI: 10.4310/SII.2016.v9.n1.a5.

2015 [20 Articles]

  1. de Leeuw C, Goudriaan A, Smit AB, Yu D, Mathews CA, Scharf JM, Verheijen MH, Posthuma D (2015) Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis. European Journal of Human Genetics, 23(11), 1519-1522. PMID: 25735483; PMCID: PMC4613465; DOI: 10.1038/ejhg.2015.22.

  2. Derringer J, Corley RP, Haberstick BC, Young SE, Demmitt BA, Howrigan DP, Kirkpatrick RM, Iacono WG, McGue M, Keller MC, Brown S, Tapert S, Hopfer CJ, Stallings MC, Crowley TJ, Rhee SH, Krauter K, Hewitt JK, McQueen MB (2015) Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. Behavior Genetics, 45(4), 375-381. PMID: 25637581; PMCID: PMC4459903; DOI: 10.1007/s10519-015-9705-y.

  3. Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA (2015) Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. Biological Psychiatry, 77(5), 493-503. PMID: 25555482; PMCID: PMC4386684; DOI: 10.1016/j.biopsych.2014.08.025.

  4. Li D, Zhao H, Kranzler HR, Li MD, Jensen KP, Zayats T, Farrer LA, Gelernter J (2015) Genome-wide association study of copy number variations (CNVs) with opioid dependence. Neuropsychopharmacology, 40(4), 1016-1026. PMID: 25345593; PMCID: PMC4330517; DOI: 10.1038/npp.2014.290.

  5. Muldoon PP, Chen J, Harenza JL, Abdullah RA, Sim-Selley LJ, Cravatt BF, Miles MF, Chen X, Lichtman AH, Damaj MI (2015) Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. British Journal of Pharmacology, 172(3), 869-882. PMID: 25258021; PMCID: PMC4301695; DOI: 10.1111/bph.12948.

  6. Palmer RH, Brick L, Nugent NR, Bidwell LC, McGeary JE, Knopik VS, Keller MC (2015) Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence. Addiction, 110(3), 530-537. PMID: 25424661; PMCID: PMC4329043; DOI: 10.1111/add.12815.

  7. Palmer RH, McGeary JE, Heath AC, Keller MC, Brick LA, Knopik VS (2015) Shared Additive Genetic Influences on DSM-IV Criteria for Alcohol Dependence in Subjects of European Ancestry. Addiction. PMID: 26211938; DOI: 10.1111/add.13070.

  8. Pan W, Chen YM, Wei P (2015) Testing for polygenic effects in genome-wide association studies. Genetic Epidemiology, 39(4), 306-316. PMID: 25847094; PMCID: PMC4406854; DOI: 10.1002/gepi.21899.

  9. Polimanti R, Yang C, Zhao H, Gelernter J (2015) Dissecting ancestry genomic background in substance dependence genome-wide association studies. Pharmacogenomics, 16(13), 1487-1498. PMID: 26267224; PMCID: PMC4632979; DOI: 10.2217/pgs.15.91.

  10. Repunte-Canonigo V, Herman M, Kawamura T, Kranzler HR, Sherva R, Gelernter J, Farrer LA, Roberto M, Sanna PP (2015) Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans. Biological Psychiatry, 77(10), 870-879. PMID: 25483400; PMCID: PMC4428692; DOI: 10.1016/j.biopsych.2014.07.031.

  11. Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Jerlhag E, Engel JA, Hodgkinson CA, Egli M, Lopez MF, Becker HC, Goldman D, Heilig M, Ramchandani VA, Leggio L (2015) The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. Translational Psychiatry, 5(6), e583. PMID: 26080318; PMCID: PMC4490279; DOI: 10.1038/tp.2015.68.

  12. Sun J, Kranzler HR, Bi J (2015) An Effective Method to Identify Heritable Components from Multivariate Phenotypes. PLOS ONE, 10(12), e0144418. PMID: 26658140; PMCID: PMC4678282; DOI: 10.1371/journal.pone.0144418.

  13. Talluri R, Shete S (2015) Evaluating methods for modeling epistasis networks with application to head and neck cancer. Cancer Informatics, 14(Suppl 2), 17-23. PMID: 25733798; PMCID: PMC4332043; DOI: 10.4137/cin.S17289.

  14. Wang KS, Zuo L, Pan Y, Xie C, Luo X (2015) Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. Journal of Psychiatric Research, 71, 1-7. PMID: 26522866; DOI: 10.1016/j.jpsychires.2015.09.008.

  15. Xu K, Kranzler HR, Sherva R, Sartor CE, Almasy L, Koesterer R, Zhao H, Farrer LA, Gelernter J (2015) Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. Alcoholism: Clinical and Experimental Research, 39(7), 1137-1147. PMID: 26036284; PMCID: PMC4706077; DOI: 10.1111/acer.12751.

  16. Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grunblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosario MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL (2015) Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCD. American Journal of Psychiatry, 172(1), 82-93. PMID: 25158072; PMCID: PMC4282594; DOI: 10.1176/appi.ajp.2014.13101306.

  17. Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X (2015) Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 168(7), 544-556. PMID: 26079129; PMCID: PMC4851708; DOI: 10.1002/ajmg.b.32329.

  18. Zuo L, Tan Y, Zhang X, Wang X, Krystal J, Tabakoff B, Zhong C, Luo X (2015) A New Genomewide Association Meta-Analysis of Alcohol Dependence. Alcoholism: Clinical and Experimental Research, 39(8), 1388-1395. PMID: 26173551; DOI: 10.1111/acer.12786.

  19. Zuo L, Wang T, Lin X, Wang J, Tan Y, Wang X, Yu X, Luo X (2015) Sex difference of autosomal alleles in populations of European and African descent. Genes Genomics, 37(12), 1007-1016. PMID: 26702338; PMCID: PMC4684836; DOI: 10.1007/s13258-015-0332-z.

  20. Zuo L, Zhang CK, Sayward FG, Cheung KH, Wang K, Krystal JH, Zhao H, Luo X (2015) Gene-based and pathway-based genome-wide association study of alcohol dependence. Shanghai Archives of Psychiatry, 27(2), 111-118. PMID: 26120261; PMCID: PMC4466852; DOI: 10.11919/j.issn.1002-0829.215031.

2014 [21 Articles]

  1. Cao J, Liu X, Han S, Zhang CK, Liu Z, Li D (2014) Association of the HTR2A gene with alcohol and heroin abuse. Human Genetics, 133(3), 357-365. PMID: 24178752; PMCID: PMC4085799; DOI: 10.1007/s00439-013-1388-y.

  2. Chen GB, Liu N, Klimentidis YC, Zhu X, Zhi D, Wang X, Lou XY (2014) A unified GMDR method for detecting gene-gene interactions in family and unrelated samples with application to nicotine dependence. Human Genetics, 133(2), 139-150. PMID: 24057800; PMCID: PMC3947150; DOI: 10.1007/s00439-013-1361-9.

  3. Feng Z (2014) A generalized quasi-likelihood scoring approach for simultaneously testing the genetic association of multiple traits. Journal of the Royal Statistical Society: Series C (Applied Statistics), 63(3), 483-498; DOI: 10.1111/rssc.12038.

  4. Gelernter J, Kranzler HR, Sherva R, Almasy L, Koesterer R, Smith AH, Anton R, Preuss UW, Ridinger M, Rujescu D, Wodarz N, Zill P, Zhao H, Farrer LA (2014) Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. Molecular Psychiatry, 19(1), 41-49. PMID: 24166409; PMCID: PMC4165335; DOI: 10.1038/mp.2013.145.

  5. Gelernter J, Kranzler HR, Sherva R, Koesterer R, Almasy L, Zhao H, Farrer LA (2014) Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways. Biological Psychiatry, 76(1), 66-74. PMID: 24143882; PMCID: PMC3992201; DOI: 10.1016/j.biopsych.2013.08.034.

  6. Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer L (2014) Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Molecular Psychiatry, 19(6), 717-723. PMID: 23958962; PMCID: PMC3865158; DOI: 10.1038/mp.2013.99.

  7. Hsieh TJ, Chang SH, Tai JJ (2014) A family-based robust multivariate association test using maximum statistic. Annals of Human Genetics, 78(2), 117-128. PMID: 24571230; DOI: 10.1111/ahg.12054.

  8. Jiang Y, Li N, Zhang H (2014) Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall’s Tau. Journal of the American Statistical Association, 109(507), 905-930. PMID: 25382885; PMCID: PMC4219655; DOI: 10.1080/01621459.2014.901223.

  9. Li D, Sulovari A, Cheng C, Zhao H, Kranzler HR, Gelernter J (2014) Association of gamma-aminobutyric acid A receptor alpha2 gene (GABRA2) with alcohol use disorder. Neuropsychopharmacology, 39(4), 907-918. PMID: 24136292; PMCID: PMC3924525; DOI: 10.1038/npp.2013.291.

  10. Li M, Gardiner JC, Breslau N, Anthony JC, Lu Q (2014) A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes. BMC Genetics, 15, 79. PMID: 24986733; PMCID: PMC4087128; DOI: 10.1186/1471-2156-15-79.

  11. Lobach I, Fan R, Manga P (2014) Genotype-based association models of complex diseases to detect gene-gene and gene-environment interactions. Statistics and Its Interface, 7(1), 51-60. PMID: 26191336; PMCID: PMC4504431; DOI: 10.4310/SII.2014.v7.n1.a6.

  12. McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O’Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosario MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grunblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM (2014) Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. Journal of the American Academy of Child and Adolescent Psychiatry, 53(8), 910-919. PMID: 25062598; PMCID: PMC4218748; DOI: 10.1016/j.jaac.2014.04.022.

  13. Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI (2014) The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies. British Journal of Pharmacology, 171(16), 3845-3857. PMID: 24750073; PMCID: PMC4128047; DOI: 10.1111/bph.12741.

  14. Song C, Zhang H (2014) TARV: tree-based analysis of rare variants identifying risk modifying variants in CTNNA2 and CNTNAP2 for alcohol addiction. Genetic Epidemiology, 38(6), 552-559. PMID: 25041903; PMCID: PMC4154634; DOI: 10.1002/gepi.21843.

  15. Taylor A, Wang KS (2014) Association between DPYSL2 gene polymorphisms and alcohol dependence in Caucasian samples. Journal of Neural Transmission (Vienna), 121(1), 105-111. PMID: 23846846; DOI: 10.1007/s00702-013-1065-2.

  16. Wang J, Yu R, Shete S (2014) X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation. Genetic Epidemiology, 38(6), 483-493. PMID: 25043884; PMCID: PMC4127090; DOI: 10.1002/gepi.21814.

  17. Wang S, A DvdV, Xu Q, Seneviratne C, Pomerleau OF, Pomerleau CS, Payne TJ, Ma JZ, Li MD (2014) Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. Human Genetics, 133(5), 575-586. PMID: 24253422; PMCID: PMC3988215; DOI: 10.1007/s00439-013-1398-9.

  18. Yang J, Li MD (2014) Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data. Human Genetics, 133(7), 905-918. PMID: 24590108; PMCID: PMC4055533; DOI: 10.1007/s00439-014-1431-7.

  19. Yuan H, Dougherty JD (2014) Investigation of maternal genotype effects in autism by genome-wide association. Autism Research, 7(2), 245-253. PMID: 24574247; PMCID: PMC3989385; DOI: 10.1002/aur.1363.

  20. Zuo L, Lu L, Tan Y, Pan X, Cai Y, Wang X, Hong J, Zhong C, Wang F, Zhang XY, Vanderlinden LA, Tabakoff B, Luo X (2014) Genome-wide association discoveries of alcohol dependence. American Journal on Addictions, 23(6), 526-539. PMID: 25278008; PMCID: PMC4187224; DOI: 10.1111/j.1521-0391.2014.12147.x.

  21. Zuo L, Wang K, Wang G, Pan X, Zhang X, Zhang H, Luo X (2014) Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence. American Journal on Addictions, 23(4), 411-414. PMID: 24961364; PMCID: PMC4111256; DOI: 10.1111/j.1521-0391.2013.12115.x.

2013 [23 Articles]

  1. Belsky DW, Moffitt TE, Baker TB, Biddle AK, Evans JP, Harrington H, Houts R, Meier M, Sugden K, Williams B, Poulton R, Caspi A (2013) Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study. JAMA Psychiatry, 70(5), 534-542. PMID: 23536134; PMCID: PMC3644004; DOI: 10.1001/jamapsychiatry.2013.736.

  2. Blaine S, Claus E, Harlaar N, Hutchison K (2013) TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence. Alcoholism: Clinical and Experimental Research, 37 Suppl 1(Suppl 1), E125-130. PMID: 23078527; PMCID: PMC5996989; DOI: 10.1111/j.1530-0277.2012.01923.x.

  3. Cui WY, Wang S, Yang J, Yi SG, Yoon D, Kim YJ, Payne TJ, Ma JZ, Park T, Li MD (2013) Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations. Molecular Psychiatry, 18(11), 1149-1151. PMID: 23319001; DOI: 10.1038/mp.2012.190.

  4. Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosario MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, Van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM (2013) Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genetics, 9(10), e1003864. PMID: 24204291; PMCID: PMC3812053; DOI: 10.1371/journal.pgen.1003864.

  5. Du M, Prescott J, Cornelis MC, Hankinson SE, Giovannucci E, Kraft P, De Vivo I (2013) Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the Nurses’ Health Study. PLOS ONE, 8(2), e52240. PMID: 23424613; PMCID: PMC3570546; DOI: 10.1371/journal.pone.0052240.

  6. Guo X, Liu Z, Wang X, Zhang H (2013) Genetic association test for multiple traits at gene level. Genetic Epidemiology, 37(1), 122-129. PMID: 23032486; PMCID: PMC3524409; DOI: 10.1002/gepi.21688.

  7. Han S, Yang BZ, Kranzler HR, Liu X, Zhao H, Farrer LA, Boerwinkle E, Potash JB, Gelernter J (2013) Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. American Journal of Human Genetics, 93(6), 1027-1034. PMID: 24268660; PMCID: PMC3853414; DOI: 10.1016/j.ajhg.2013.10.021.

  8. Liu Z, Guo X, Jiang Y, Zhang H (2013) NCK2 is significantly associated with opiates addiction in African-origin men. The Scientific World Journal, 2013, 748979. PMID: 23533358; PMCID: PMC3603435; DOI: 10.1155/2013/748979.

  9. Lopes AM, Aston KI, Thompson E, Carvalho F, Gon�alves J, Huang N, Matthiesen R, Noordam MJ, Quintela I, Ramu A, Seabra C, Wilfert AB, Dai J, Downie JM, Fernandes S, Guo X, Sha J, Amorim A, Barros A, Carracedo A, Hu Z, Hurles ME, Moskovtsev S, Ober C, Paduch DA, Schiffman JD, Schlegel PN, Sousa M, Carrell DT, Conrad DF (2013) Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1. PLoS Genetics, 9(3), e1003349. PMID: 23555275; PMCID: PMC3605256; DOI: 10.1371/journal.pgen.1003349.

  10. Pan Y, Luo X, Liu X, Wu LY, Zhang Q, Wang L, Wang W, Zuo L, Wang KS (2013) Genome-wide association studies of maximum number of drinks. Journal of Psychiatric Research, 47(11), 1717-1724. PMID: 23953852; PMCID: PMC4286179; DOI: 10.1016/j.jpsychires.2013.07.013.

  11. Pan Y, Wang KS, Wang L, Wu LY (2013) Common variants in HLA-DRA gene are associated with alcohol dependence in two Caucasian samples. Journal of Molecular Neuroscience, 49(3), 574-581. PMID: 22890421; DOI: 10.1007/s12031-012-9869-3.

  12. Ray LA, Sehl M, Bujarski S, Hutchison K, Blaine S, Enoch MA (2013) The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G × E effects. Genes, Brain and Behavior, 12(4), 361-369. PMID: 23473364; PMCID: PMC4139150; DOI: 10.1111/gbb.12032.

  13. Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrio GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, North American Brain Expression Consortium, Hardy J, U. K. Human Brain Expression Database, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL (2013) Genome-wide association study of Tourette’s syndrome. Molecular Psychiatry, 18(6), 721-728. PMID: 22889924; PMCID: PMC3605224; DOI: 10.1038/mp.2012.69.

  14. Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH, Jr., Kennedy JL, Rosenberg D, Stein DJ, Hemmings SM, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Umana P, Murphy DL, Wendland JR, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg HG, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Conceicao do Rosario M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A, North American Brain Expression Consortium, Hardy J, U. K. Brain Expression Database, Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL (2013) Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry, 18(7), 788-798. PMID: 22889921; PMCID: PMC4218751; DOI: 10.1038/mp.2012.85.

  15. Wang L, Liu X, Luo X, Zeng M, Zuo L, Wang KS (2013) Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence. Journal of Molecular Neuroscience, 51(2), 416-424. PMID: 23771786; DOI: 10.1007/s12031-013-0044-2.

  16. Wen Y, Schaid DJ, Lu Q (2013) A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity. Genetic Epidemiology, 37(3), 248-255. PMID: 23334941; PMCID: PMC3760410; DOI: 10.1002/gepi.21709.

  17. Zuo L, Saba L, Wang K, Zhang X, Krystal JH, Tabakoff B, Luo X (2013) Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence. Journal of Studies on Alcohol and Drugs, 74(4), 622-625. PMID: 23739027; PMCID: PMC3711352; DOI: 10.15288/jsad.2013.74.622.

  18. Zuo L, Wang K, Zhang X, Pan X, Wang G, Krystal JH, Zhang H, Luo X (2013) Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence. Psychiatric Genetics, 23(6), 233-238. PMID: 23907288; PMCID: PMC3941913; DOI: 10.1097/YPG.0b013e328364b8c7.

  19. Zuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X (2013) NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug and Alcohol Dependence, 129(3), 254-264. PMID: 23455491; PMCID: PMC3628730; DOI: 10.1016/j.drugalcdep.2013.02.006.

  20. Zuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X (2013) Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. Human Genetics, 132(7), 735-743. PMID: 23468174; PMCID: PMC3683370; DOI: 10.1007/s00439-013-1277-4.

  21. Zuo L, Wang KS, Zhang XY, Li CS, Zhang F, Wang X, Chen W, Gao G, Zhang H, Krystal JH, Luo X (2013) Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. Pharmacogenetics and Genomics, 23(8), 395-402. PMID: 23778322; PMCID: PMC4287355; DOI: 10.1097/FPC.0b013e328362f9f2.

  22. Zuo L, Zhang H, Malison RT, Li CS, Zhang XY, Wang F, Lu L, Lu L, Wang X, Krystal JH, Zhang F, Deng HW, Luo X (2013) Rare ADH variant constellations are specific for alcohol dependence. Alcohol and Alcoholism, 48(1), 9-14. PMID: 23019235; PMCID: PMC3523382; DOI: 10.1093/alcalc/ags104.

  23. Zuo L, Zhang XY, Wang F, Li CS, Lu L, Ye L, Zhang H, Krystal JH, Deng HW, Luo X (2013) Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence. Alcoholism: Clinical and Experimental Research, 37(5), 730-739. PMID: 23216389; PMCID: PMC3610804; DOI: 10.1111/acer.12032.

2012 [16 Articles]

  1. Fang YH, Chiu YF (2012) SVM-based generalized multifactor dimensionality reduction approaches for detecting gene-gene interactions in family studies. Genetic Epidemiology, 36(2), 88-98. PMID: 22851472; DOI: 10.1002/gepi.21602.

  2. Frank J, Cichon S, Treutlein J, Ridinger M, Mattheisen M, Hoffmann P, Herms S, Wodarz N, Soyka M, Zill P, Maier W, Mössner R, Gaebel W, Dahmen N, Scherbaum N, Schmäl C, Steffens M, Lucae S, Ising M, Müller-Myhsok B, Nöthen MM, Mann K, Kiefer F, Rietschel M (2012) Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. Addiction Biology, 17(1), 171-180. PMID: 22004471; PMCID: PMC3245349; DOI: 10.1111/j.1369-1600.2011.00395.x.

  3. Guo X, Liu Z, Wang X, Zhang H (2012) Large scale association analysis for drug addiction: results from SNP to gene. ScientificWorldJournal, 2012, 939584. PMID: 23365539; PMCID: PMC3543790; DOI: 10.1100/2012/939584.

  4. Han S, Yang BZ, Kranzler HR, Oslin D, Anton R, Farrer LA, Gelernter J (2012) Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. Biological Psychiatry, 72(8), 637-644. PMID: 22520967; PMCID: PMC3699339; DOI: 10.1016/j.biopsych.2012.02.038.

  5. Jackson KJ, Sanjakdar SS, Chen X, Damaj MI (2012) Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout mice. PLOS ONE, 7(11), e51154. PMID: 23226481; PMCID: PMC3511389; DOI: 10.1371/journal.pone.0051154.

  6. Karpyak VM, Geske JR, Colby CL, Mrazek DA, Biernacka JM (2012) Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. Addiction Biology, 17(4), 798-806. PMID: 21762291; PMCID: PMC3197973; DOI: 10.1111/j.1369-1600.2011.00338.x.

  7. Listgarten J, Lippert C, Kadie CM, Davidson RI, Eskin E, Heckerman D (2012) Improved linear mixed models for genome-wide association studies. Nature Methods, 9(6), 525-526. PMID: 22669648; PMCID: PMC3597090; DOI: 10.1038/nmeth.2037.

  8. Shirley MD, Baugher JD, Stevens EL, Tang Z, Gerry N, Beiswanger CM, Berlin DS, Pevsner J (2012) Chromosomal variation in lymphoblastoid cell lines. Human Mutation, 33(7), 1075-1086. PMID: 22374857; PMCID: PMC3370055; DOI: 10.1002/humu.22062.

  9. Thornton T, Zhang Q, Cai X, Ober C, McPeek MS (2012) XM: association testing on the X-chromosome in case-control samples with related individuals. Genetic Epidemiology, 36(5), 438-450. PMID: 22552845; PMCID: PMC3762984; DOI: 10.1002/gepi.21638.

  10. Wang KS, Liu X, Aragam N, Mullersman JE, Jian X, Pan Y, Liu Y (2012) Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. Journal of Molecular Neuroscience, 46(2), 265-271. PMID: 21547531; DOI: 10.1007/s12031-011-9530-6.

  11. Wang KS, Liu X, Zhang Q, Wu LY, Zeng M (2012) Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. Journal of Neural Transmission (Vienna), 119(4), 425-433. PMID: 22072270; DOI: 10.1007/s00702-011-0729-z.

  12. Wang KS, Liu X, Zhang Q, Zeng M (2012) ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. Drug and Alcohol Dependence, 124(3), 325-332. PMID: 22377092; DOI: 10.1016/j.drugalcdep.2012.02.003.

  13. Wang KS, Liu X, Zheng S, Zeng M, Pan Y, Callahan K (2012) A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. Gene, 500(1), 80-84. PMID: 22446040; DOI: 10.1016/j.gene.2012.03.046.

  14. Zhu W, Jiang Y, Zhang H (2012) Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall’s Tau(). Journal of the American Statistical Association, 107(497), 1-11. PMID: 22745516; PMCID: PMC3381868; DOI: 10.1080/01621459.2011.643707.

  15. Zuo L, Gelernter J, Zhang CK, Zhao H, Lu L, Kranzler HR, Malison RT, Li CS, Wang F, Zhang XY, Deng HW, Krystal JH, Zhang F, Luo X (2012) Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. Neuropsychopharmacology, 37(2), 557-566. PMID: 21956439; PMCID: PMC3242317; DOI: 10.1038/npp.2011.229.

  16. Zuo L, Zhang F, Zhang H, Zhang XY, Wang F, Li CS, Lu L, Hong J, Lu L, Krystal J, Deng HW, Luo X (2012) Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 159b(4), 437-444. PMID: 22488850; PMCID: PMC3405545; DOI: 10.1002/ajmg.b.32047.

2011 [11 Articles]

  1. Chen X, Cho K, Singer BH, Zhang H (2011) The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. PLOS ONE, 6(1), e16002. PMID: 21298047; PMCID: PMC3029286; DOI: 10.1371/journal.pone.0016002.

  2. Drgon T, Johnson CA, Nino M, Drgonova J, Walther DM, Uhl GR (2011) “Replicated” genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 156(2), 125-138. PMID: 21302341; PMCID: PMC3282182; DOI: 10.1002/ajmg.b.31143.

  3. Feng Z, Wong WWL, Gao X, Schenkel F (2011) Generalized genetic association study with samples of related individuals. The Annals of Applied Statistics, 5(3), 2109-2130, 2122; LINK.

  4. Jian XQ, Wang KS, Wu TJ, Hillhouse JJ, Mullersman JE (2011) Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies. Journal of Abnormal Child Psychology, 39(6), 773-782. PMID: 21611732; DOI: 10.1007/s10802-011-9524-4.

  5. Johnson C, Drgon T, Walther D, Uhl GR (2011) Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. PLOS ONE, 6(7), e19210. PMID: 21818250; PMCID: PMC3144872; DOI: 10.1371/journal.pone.0019210.

  6. Lippert C, Listgarten J, Liu Y, Kadie CM, Davidson RI, Heckerman D (2011) FaST linear mixed models for genome-wide association studies. Nature Methods, 8(10), 833-835. PMID: 21892150; DOI: 10.1038/nmeth.1681.

  7. Pan Y, Wang KS, Aragam N (2011) NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(1), 154-160. PMID: 21036197; DOI: 10.1016/j.pnpbp.2010.10.016.

  8. Wang KS, Liu X, Aragam N, Jian X, Mullersman JE, Liu Y, Pan Y (2011) Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. J Neural Transm (Vienna), 118(9), 1293-1299. PMID: 21445666; DOI: 10.1007/s00702-011-0628-3.

  9. Wang KS, Liu X, Zhang Q, Pan Y, Aragam N, Zeng M (2011) A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. Journal of Psychiatric Research, 45(11), 1419-1425. PMID: 21703634; DOI: 10.1016/j.jpsychires.2011.06.005.

  10. Wang Z (2011) Direct assessment of multiple testing correction in case-control association studies with related individuals. Genetic Epidemiology, 35(1), 70-79. PMID: 21181898; DOI: 10.1002/gepi.20555.

  11. Zuo L, Zhang CK, Wang F, Li CS, Zhao H, Lu L, Zhang XY, Lu L, Zhang H, Zhang F, Krystal JH, Luo X (2011) A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study. PLOS ONE, 6(11), e26726. PMID: 22096494; PMCID: PMC3210123; DOI: 10.1371/journal.pone.0026726.

2010 [7 Articles]

  1. Chiu YF, Chiou JM, Liang KY, Lee CY (2010) Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs. BMC Genetics, 11, 67. PMID: 20626914; PMCID: PMC3247820; DOI: 10.1186/1471-2156-11-67.

  2. Diao G, Lin DY (2010) Variance-components methods for linkage and association analysis of ordinal traits in general pedigrees. Genetic Epidemiology, 34(3), 232-237. PMID: 19918762; PMCID: PMC3003595; DOI: 10.1002/gepi.20453.

  3. Drgon T, Zhang PW, Johnson C, Walther D, Hess J, Nino M, Uhl GR (2010) Genome wide association for addiction: replicated results and comparisons of two analytic approaches. PLOS ONE, 5(1), e8832. PMID: 20098672; PMCID: PMC2809089; DOI: 10.1371/journal.pone.0008832.

  4. Han S, Gelernter J, Luo X, Yang BZ (2010) Meta-analysis of 15 genome-wide linkage scans of smoking behavior. Biological Psychiatry, 67(1), 12-19. PMID: 19819424; PMCID: PMC2975396; DOI: 10.1016/j.biopsych.2009.08.028.

  5. Noor A, Whibley A, Marshall CR, Gianakopoulos PJ, Piton A, Carson AR, Orlic-Milacic M, Lionel AC, Sato D, Pinto D, Drmic I, Noakes C, Senman L, Zhang X, Mo R, Gauthier J, Crosbie J, Pagnamenta AT, Munson J, Estes AM, Fiebig A, Franke A, Schreiber S, Stewart AF, Roberts R, McPherson R, Guter SJ, Cook EH, Jr., Dawson G, Schellenberg GD, Battaglia A, Maestrini E, Autism Genome Project C, Jeng L, Hutchison T, Rajcan-Separovic E, Chudley AE, Lewis SM, Liu X, Holden JJ, Fernandez B, Zwaigenbaum L, Bryson SE, Roberts W, Szatmari P, Gallagher L, Stratton MR, Gecz J, Brady AF, Schwartz CE, Schachar RJ, Monaco AP, Rouleau GA, Hui CC, Lucy Raymond F, Scherer SW, Vincent JB (2010) Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. Science Translational Medicine, 2(49), 49ra68. PMID: 20844286; PMCID: PMC2987731; DOI: 10.1126/scitranslmed.3001267.

  6. Thornton T, McPeek MS (2010) ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure. American Journal of Human Genetics, 86(2), 172-184. PMID: 20137780; PMCID: PMC2820184; DOI: 10.1016/j.ajhg.2010.01.001.

  7. Zhang H, Liu CT, Wang X (2010) An Association Test for Multiple Traits Based on the Generalized Kendall’s Tau. Journal of the American Statistical Association, 105(490), 473-481. PMID: 20711441; PMCID: PMC2920220; DOI: 10.1198/jasa.2009.ap08387.

2009 [1 Article]

  1. Wang Z, McPeek MS (2009) An Incomplete-Data Quasi-likelihood Approach to Haplotype-Based Genetic Association Studies on Related Individuals. Journal of the American Statistical Association, 104(487), 1251-1260. PMID: 20428335; PMCID: PMC2860453; DOI: 10.1198/jasa.2009.tm08507.

2008 [7 Articles]

  1. Feng R, Zhang H (2008) A genomic imprinting test for ordinal traits in pedigree data. Genetic Epidemiology, 32(2), 132-142. PMID: 17922481; DOI: 10.1002/gepi.20270.

  2. Feng R, Zhang H (2008) A score test for linkage analysis of ordinal traits based on IBD sharing. Biostatistics, 9(1), 114-127. PMID: 17519391; DOI: 10.1093/biostatistics/kxm016.

  3. Ishiguro H, Gong JP, Hall FS, Arinami T, Uhl GR (2008) Association of PTPRB gene polymorphism with drug addiction. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147b(7), 1167-1172. PMID: 18361428; DOI: 10.1002/ajmg.b.30742.

  4. Jacobson KC, Beseler CL, Lasky-Su J, Faraone SV, Glatt SJ, Kremen WS, Lyons MJ, Tsuang MT (2008) Ordered subsets linkage analysis of antisocial behavior in substance use disorder among participants in the Collaborative Study on the Genetics of Alcoholism. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147b(7), 1258-1269. PMID: 18496835; PMCID: PMC4248599; DOI: 10.1002/ajmg.b.30771.

  5. Jonasdottir G, Becker T, Humphreys K, Palmgren J (2008) Testing association in the presence of linkage using the GRE and multiple markers. Genetic Epidemiology, 32(5), 425-433. PMID: 18271023; DOI: 10.1002/gepi.20315.

  6. Kim Y, Duggal P, Gillanders EM, Kim H, Bailey-Wilson JE (2008) Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data. Genetic Epidemiology, 32(1), 41-51. PMID: 17685456; PMCID: PMC2216429; DOI: 10.1002/gepi.20260.

  7. Yang HC, Hsieh HY, Fann CS (2008) Kernel-based association test. Genetics, 179(2), 1057-1068. PMID: 18558654; PMCID: PMC2429859; DOI: 10.1534/genetics.107.084616.

2007 [4 Articles]

  1. Dietter J, Mattheisen M, Furst R, Ruschendorf F, Wienker TF, Strauch K (2007) Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE. Bioinformatics, 23(1), 64-70. PMID: 17060360; DOI: 10.1093/bioinformatics/btl539.

  2. Ducci F, Enoch MA, Funt S, Virkkunen M, Albaugh B, Goldman D (2007) Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populations. Alcohol, 41(1), 3-12. PMID: 17452294; PMCID: PMC1924490; DOI: 10.1016/j.alcohol.2007.02.005.

  3. Ishiguro H, Walther D, Arinami T, Uhl GR (2007) Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples. Addiction, 102(8), 1320-1325. PMID: 17624982; DOI: 10.1111/j.1360-0443.2007.01877.x.

  4. Thornton T, McPeek MS (2007) Case-control association testing with related individuals: a more powerful quasi-likelihood score test. American Journal of Human Genetics, 81(2), 321-337. PMID: 17668381; PMCID: PMC1950805; DOI: 10.1086/519497.

2006 [4 Articles]

  1. Diao G, Lin DY (2006) Improving the power of association tests for quantitative traits in family studies. Genetic Epidemiology, 30(4), 301-313. PMID: 16607624; DOI: 10.1002/gepi.20145.

  2. Diao G, Lin DY (2006) Semiparametric variance-component models for linkage and association analyses of censored trait data. Genetic Epidemiology, 30(7), 570-581. PMID: 16858699; DOI: 10.1002/gepi.20168.

  3. Wang X, Ye Y, Zhang H (2006) Family-based association tests for ordinal traits adjusting for covariates. Genetic Epidemiology, 30(8), 728-736. PMID: 17086513; DOI: 10.1002/gepi.20184.

  4. Zhang H, Wang X, Ye Y (2006) Detection of genes for ordinal traits in nuclear families and a unified approach for association studies. Genetics, 172(1), 693-699. PMID: 16219774; PMCID: PMC1456175; DOI: 10.1534/genetics.105.049122.

1999 [1 Article]

  1. Sheffield LJ, Knauert MP, Pakstis AJ, Zhao H, Kidd KK (1999) Analyses of the COGA data set in one ethnic group with examinations of alternative definitions of alcoholism. Genetic Epidemiology, 17 Suppl 1, S319-324. PMID: 10597456; DOI: 10.1002/gepi.1370170754.