The Collaborative Study On The Genetics Of Alcoholism: Genetics

This review presents a comprehensive evaluation of genetic methodologies and findings stemming from the family-centered Collaborative Study on the Genetics of Alcoholism (COGA). COGA’s primary objective was to identify genes influencing the susceptibility to alcohol use disorder (AUD) and its related complications. Notably, COGA was an early adopter of genome-wide association studies (GWAS) while also […]

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The Collaborative Study On The Genetics Of Alcoholism: Sample and Clinical Data

This article offers an overview of the methodologies offered in collecting data for the COGA study and also dives into the characteristics of the study sample and clinical information. This is a second installment of a 5 paper series.  The Collaborative Study on the Genetics of Alcoholism (COGA) is a comprehensive multidisciplinary research initiative aimed at […]

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The Collaborative Study on the Genetics of Alcoholism: Overview

Alcohol use disorders (AUD) are common conditions influenced by both genetics and the environment. They can lead to various problems related to excessive alcohol consumption. To comprehensively investigate the causes and consequences of alcohol-related milestones, including AUD and associated psychiatric conditions, the Collaborative Study on the Genetics of Alcoholism (COGA) was established in 1989.  COGA […]

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Multivariate Genome-wide Association Meta-analysis Of Over 1 Million Subjects Identifies Loci Underlying Multiple Substance Use Disorders

This comprehensive study investigates the genetic factors contributing to substance use disorders (SUDs), including alcohol, tobacco, cannabis, and opioid use. It encompasses a vast dataset with over a million participants, representing diverse populations.    Researchers took several steps to investigate the genetic factors associated with substance use disorders (SUDs). First, they categorized the effects of […]

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The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment

This study delves into the complex involvement of the amyloid precursor protein (APP) in Alzheimer’s disease (AD). While APP is primarily known for its connection to the production of β-amyloid (Aβ) peptides, a characteristic of AD brains, this research uncovers a different facet of its functionality. It reveals a unique link between APP and neuronal […]

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RNA Alternative Splicing Impacts The Risk For Alcohol Use Disorder

Researchers investigate how RNA alternative splicing, a process where genes create different versions of their instructions, might be linked to alcohol use disorder (AUD). Previous research found changes in RNA splicing in the brains of individuals with AUD, but it’s unclear if these changes contribute to the disorder. The challenge is the lack of large-scale […]

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Alcohol Reverses The Effects Of KCNJ6 (GIRK2) Noncoding Variants On Excitability Of Human Glutamatergic Neurons

Researchers focused on variations within the KCNJ6 gene, which encodes the GIRK2 protein responsible for regulating cell excitability, including responses to alcohol. To investigate this further, the study utilizes a human neuron model system, including individuals with the ERO-associated allelic variant in KCNJ6 and diagnosed alcohol dependence, as well as those without the variant and unaffected […]

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Do Personality Characteristics Predict Future Alcohol Problems After Considering Current Demography, Substance Use, And Alcohol Response?

Certain personality traits have been identified as predictors of future alcohol-related issues. However, these traits are also connected to various demographic and substance-related factors and few studies have investigated whether personality traits continue to predict alcohol problems when accounting for current demographic and substance-related factors.   This study followed 414 non-alcohol use disorder (AUD) drinkers […]

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Genomic Risk For Post-traumatic Stress Disorder In Families Densely Affected With Alcohol Use Disorders

Post-traumatic stress disorder (PTSD) is a condition that occurs after experiencing a traumatic event. Although many people are exposed to trauma, only a small percentage develop PTSD. Studies that look at the entire genome (genome-wide association studies or GWAS) have found specific genetic signs related to PTSD in both civilian and military groups. However, studies […]

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Upregulated GIRK2 Counteracts Ethanol-induced Changes In Excitability And Respiration In Human Neurons

This research identified specific genetic variations in the KCNJ6 gene linked to changes in brain activity measured through electroencephalogram (EEG) frontal theta event-related oscillations (θ-EROs) during cognitive tasks. These variations are associated with alcohol use disorder (AUD) and are considered to be a sign of susceptibility to AUD. The KCNJ6 gene encodes the GIRK2 protein, […]

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