Obsessive-compulsive disorder (OCD) affects approximately 1% of the population and has a strong genetic component. This study combined data from 53,660 OCD cases and 2,044,417 controls of European ancestry, identifying 30 genetic markers strongly associated with OCD and finding that genetic factors explain 6.7% of the risk. Separate analyses for different sub-groups of OCD, such […]
Researchers studied brain wave patterns (EEG coherence) in a group of 1426 participants aged 12 to 31 in order to better understand how brain connections develop in teens and young adults. They looked at specific brain activity (high alpha frequency) across 27 pairs of brain regions, resulting in 5006 observations. Using statistical methods, they analyzed […]
Post-traumatic stress disorder (PTSD) is a mental health condition that can develop after experiencing a traumatic event. It’s characterized by symptoms like intrusive thoughts, heightened arousal, avoiding reminders of the trauma, and negative changes in mood and thinking. For some individuals, these symptoms persist long after the traumatic experience has ended, significantly impacting their quality […]
This article offers an overview of the methodologies offered in collecting data for the COGA study and also dives into the characteristics of the study sample and clinical information. This is a second installment of a 5 paper series. The Collaborative Study on the Genetics of Alcoholism (COGA) is a comprehensive multidisciplinary research initiative aimed at […]
This study delves into the complex involvement of the amyloid precursor protein (APP) in Alzheimer’s disease (AD). While APP is primarily known for its connection to the production of β-amyloid (Aβ) peptides, a characteristic of AD brains, this research uncovers a different facet of its functionality. It reveals a unique link between APP and neuronal […]
Post-traumatic stress disorder (PTSD) is a condition that occurs after experiencing a traumatic event. Although many people are exposed to trauma, only a small percentage develop PTSD. Studies that look at the entire genome (genome-wide association studies or GWAS) have found specific genetic signs related to PTSD in both civilian and military groups. However, studies […]
Researchers aimed to understand memory problems in older adults with a history of alcohol use disorder (AUD) using a machine learning approach. Comparisons were made between a group of 94 adults aged 50-81 with alcohol-induced memory problems (Memory group) to a matched Control group without memory issues. The Random Forests model identified specific features from […]
